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FLASH GENE
Symbol ACOT4 contributors: SGE/npt - updated : 23-03-2010
HGNC name acyl-CoA thioesterase 4
HGNC id 19748
Location 14q24.3      Physical location : 74.058.409 - 74.062.468
Synonym name
  • peroxisomal acyl-CoA thioesterase 2B
  • peroxisomal long-chain acyl-CoA thioesterase Ib
  • peroxisomal acyl coenzyme A thioester hydrolase Ib
  • Synonym symbol(s) PTE1B, PTE2B, PTE-Ib, FLJ31235
    EC.number 3.1.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 4.06 kb     3 Exon(s)
    MAPPING cloned Y linked N status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1703 - 421 - Hunt (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveliver   highly
    Reproductivefemale systemplacenta  lowly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Acot4
    Homologene
    FAMILY
  • C/M/P thioester hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • hydrolase activity
  • catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH
  • mainly hydrolyzes succinyl-CoA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS