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FLASH GENE
Symbol ACOT2 contributors: mct/npt - updated : 17-06-2008
HGNC name acyl-CoA thioesterase 2
HGNC id 18431
Location 14q24.3      Physical location : 74.035.771 - 74.042.357
Synonym name
  • peroxisomal long-chain acyl-coA thioesterase
  • mitochondrial acyl-CoA thioesterase 2
  • long-chain acyl-CoA thioesterase 2
  • ortholog of mouse peroxisomal acyl-CoA thioesterase Ic
    • Synonym symbol(s) PTE2, PTE2A, ZAP128, Mte1, CTE-Ia
    EC.number 3.1.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1767 53.2 483 - Ewing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminal tripeptide sequence serine-lysine-valine-COOH
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Cte1
    Homologene
    FAMILY
  • C/M/P thioester hydrolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acyl-CoA thioesterase activity
  • involved in steroid synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    medium and long chain fatty acids, acyl-CoA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS