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FLASH GENE
Symbol ACOT1 contributors: KTN/npt - updated : 25-06-2008
HGNC name acyl-CoA thioesterase 1
HGNC id 33128
Location 14q24.3      Physical location : 74.003.927 - 74.010.498
Synonym name
  • inducible cytosolic acyl-coenzyme A thioester hydrolase
  • long chain acyl-CoA thioester hydrolase
  • Synonym symbol(s) ACH2, CTE-1, LACH2, CTE-Ib, CTE-I
    EC.number 3.1.2.2
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1603 46 421 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestine   moderately
     pancreas exocrine   moderately
    Endocrineparathyroid   predominantly
    Reproductivefemale systemovary  moderately
     male systemprostate  moderately
    Respiratorylung   moderately
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Acot3 (76.7 pc)
    Homologene
    FAMILY
  • C/M/P thioester hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • very-long-chain and long-chain fatty acid metabolic process
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS