basic FUNCTION
| ATP-citrate lyase, used as a substrate for synthesis of the cytosolic acetyl-CoA |
|
having a central role in lipid synthesis |
|
in nervous tissue it may be involved in the biosynthesis of acetylcholine |
|
ACL activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene  |
|
ACLY expression and activity can be suppressed by exogenous lipids, demonstrating a critical role for ACLY in pancreatic beta cell survival  |
|
is likely important for the pyruvate citrate shuttle and lipid synthesis in insulin secretion  |
|
direct role for ACLY in macrophage inflammatory metabolism  |
|
potential function of ACLY in cellular senescence and tumorigenesis  |
|
cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA  |
|
ACACA and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate  |
|
controls a glucose-to-acetate metabolic switch  |
|
critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis  |
|
key enzyme linking aerobic glycolysis and fatty acid synthesis that is of high biological and prognostic significance in breast cancer  |
|
facilitates histone acetylation at double-strand break (DSB) sites, impairing TP53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination  |
|
the spatial and temporal control of acetyl-CoA production by ACLY participates in the mechanism of DNA repair pathway choice  |