| basic FUNCTION
| ATP-citrate lyase, used as a substrate for synthesis of the cytosolic acetyl-CoA |
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having a central role in lipid synthesis |
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in nervous tissue it may be involved in the biosynthesis of acetylcholine |
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ACL activity is required to link growth factor-induced increases in nutrient metabolism to the regulation of histone acetylation and gene  |
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ACLY expression and activity can be suppressed by exogenous lipids, demonstrating a critical role for ACLY in pancreatic beta cell survival |
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is likely important for the pyruvate citrate shuttle and lipid synthesis in insulin secretion |
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direct role for ACLY in macrophage inflammatory metabolism |
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potential function of ACLY in cellular senescence and tumorigenesis |
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cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA |
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ACACA and ACLY regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate |
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controls a glucose-to-acetate metabolic switch |
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critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis |
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key enzyme linking aerobic glycolysis and fatty acid synthesis that is of high biological and prognostic significance in breast cancer |
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facilitates histone acetylation at double-strand break (DSB) sites, impairing TP53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination |
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the spatial and temporal control of acetyl-CoA production by ACLY participates in the mechanism of DNA repair pathway choice |
