| basic FUNCTION
| erythrocyte receptor for chemokines and plasmodium vivax |
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having a role in enhancing leukocyte recruitment to sites of inflammation by facilitating movement of chemokines across the endothelium |
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may play a role at local level by binding locally produced chemokines in psoriasis vulgaris |
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playing an essential role for the function of CD82 as a suppressor of metastasis |
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on endothelial cells plays a direct role in regulating angiogenesis, attenuating the angiogenic activity by causing senescence  |
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substantially alters chemokine concentrations in blood, but it does not have a protective effect during human endotoxemia |
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regulates lung inflammation by controlling the distribution and presentation of chemokines that bind CXCR2 |
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carries antigens that are important in blood transfusion and is the main receptor used by Plasmodium vivax to invade reticulocytes |
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implicated in multiple chemokine inflammation, inflammatory diseases, in cancer and might play a role in HIV infection and AIDS |
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role of the Duffy glycoprotein as a chemokine receptor and in malarial infection |
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regulator of almost every CC and CXC chemokine ligand and therefore DARC antagonism could effectively block the complex pre-inflammatory chemokine network |
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(PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (ACKR1) are necessary for platelet-mediated killing of Plasmodium falciparum parasites |
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plays a role in modulating the early inflammatory response to bone fracture and subsequent cartilage formation |
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role for erythrocyte ACKR1 as a chemokine reservoir and endothelial ACKR1 contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier |
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ACKR1 knockdown increases the migration and invasion abilities of keloid fibroblasts |
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is required for S. aureus-mediated lysis of human erythrocytes, and ACKR1 overexpression is sufficient to render cells susceptible to toxin-mediated lysis |
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fundamental role for ACKR1 in hematopoiesis |
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nucleated erythroid cells had high expression of ACKR1, which facilitated their direct contact with hematopoietic stem cells |
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ACKR1 extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism |
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regulates likely metabolic function and adipose tissue inflammation, which may impact obesity-related disease in ethnic populations with high frequencies of ACKR1 allelic variants |
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might have a role to play in severe malaria |
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might be tumor suppressor for Cervical cancer |
