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FLASH GENE
Symbol ACIN1 contributors: mct - updated : 02-01-2012
HGNC name apoptotic chromatin condensation inducer 1
HGNC id 17066
Location 14q11.2      Physical location : 23.527.775 - 23.564.823
Synonym name
  • like ortholog of mouse acinus
  • cDNA sequence,expressed in brain, >100kDa, related to V1 small nuclear ribonucleoprotein 70 kDa (SURP70)
  • functional spliceosome-associated protein 152
  • apoptotic chromatin condensation inducer in the nucleus
  • functional spliceosome-associated protein 152
  • Synonym symbol(s) ACN, KIAA0670, ACINUS, fSAP152, DKFZp667N107
    DNA
    TYPE functioning gene
    STRUCTURE 37.05 kb     19 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 splicing 4951 - 1341 - 1999 10490026
    also called acinus L
    13 splicing 2529 - 583 - 1999 10490026
    also called acinus S
    12 - 2467 - 614 - 1999 10490026
    also called acinus S'
    18 - 4828 - 1301 - 1999 10490026
    19 - 4909 - 1328 - 1999 10490026
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • with RNPS1, contain typical motifs of splicing regulatory proteins including arginine/serine-rich domains
  • HOMOLOGY
    interspecies ortholog to murine acinus-pending
    intraspecies homolog to U1 small nuclear ribonucleoprotein 70 kDa (SURP70)
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • inducting apoptotic chromatin condensation
  • also involved in mRNA splicing and a component of the apoptosis and splicing-associated protein (ASAP) complex
  • nuclear factor that has been suggested to mediate apoptotic chromatin condensation after caspase cleavage
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • AKT1/NF-kappaB/ACIN1 pathway functions as one of the important regulatory mechanisms required for modulating ionizing radiation sensitivity
  • RNPS1, ACIN1, and SAP18 form the apoptosis- and splicing-associated protein (ASAP) complex, which is also part of the exon junction complex
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • direct target of AKT1 (AKT1 phosphorylation of acinus on serine 422 and 573 results in its resistance to caspase cleavage in the nucleus and the inhibition of acinus-dependent chromatin condensation)
  • NGF is a cognate ligand for the neurotrophic receptor NTRK1, promoting the interaction between CTBP2 and ACIN1 through triggering ACIN1 phosphorylation by AKT1
  • API5, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to ACIN1 and prevents ACIN1-mediated DNA fragmentation
  • SAP18 assembles a nuclear speckle-localized splicing regulatory multiprotein complex including RNPS1 and ACIN1 via its ubiquitin-like fold
  • cell & other
    REGULATION
    activated by cleavage by caspase-3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with SRPK2 in some human acute myelogenous leukemia patients and correlate with elevated cyclin A1 expression levels (Jang 2008)
    tumoral     --low  
    by hypermethylation of the ACIN1 gene in early stage lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS