basic FUNCTION
| dipeptyl carboxypeptidase 1 (angiotensin I converting enzyme), involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II |
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significant role for ACE in myelopoiesis |
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intrarenal ACE and ACE2 may play an important role in the pathogenesis and progression of hypertensive nephrosclerosis (HTN) |
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displays a key role on its own downregulation in response to shear-stress (SS) |
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cell-surface marker of adult human hematopoietic stem cells, but is already expressed in all presumptive and developing blood-forming tissues of the human embryo and fetus |
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is involved in the regulation of human blood formation |
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zinc dependent peptidase with a major role in regulating vasoactive peptide metabolism |
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key regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone and kallikrein-kinin systems |
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ACE metabolism plays a fundamental role in the responses of the kidney to hypertensive stimuli, and renal ACE activity is required to increase local AGT, to stimulate sodium transport in loop of Henle and the distal nephron, and to induce hypertension |
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key regulator of blood pressure and electrolyte fluid homeostasis, cleaves the vasoactive angiotensin-I, bradykinin, and a number of other physiologically relevant peptides |