Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ACADM contributors: mct/npt - updated : 22-06-2009
HGNC name acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
HGNC id 89
Corresponding disease
ACADM medium-chain acylcarnitine deficiency
Location 1p31.1      Physical location : 76.190.042 - 76.229.353
Synonym name medium-chain acyl-CoA dehydrogenase
Synonym symbol(s) MCAD, ACAD1, MCADH, FLJ18227, FLJ93013, FLJ99884
EC.number 1.3.99.3
DNA
TYPE functioning gene
STRUCTURE 39.31 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2615 43.6 421 - O'Reilly (2005)
13 - 2627 43.64 425 - O'Reilly (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumcardiac highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal all-alpha domain
  • transmembrane domain
  • C terminal all-alpha, four helical up-and-down bundle
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • acyl-CoA dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • acyl-CoA dehydrogenase, medium chain (C6-C12), fatty acid beta-oxidation, first step, transferring an electron to ETF
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • FAD+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACADM
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS