Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

ACADM

contributors: mct/npt - updated : 22-06-2009

HGNC name	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain
HGNC id	89

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ACADM medium-chain acylcarnitine deficiency
Location	1p31.1      Physical location : 76.190.042 - 76.229.353
Synonym name	medium-chain acyl-CoA dehydrogenase
Synonym symbol(s)	MCAD, ACAD1, MCADH, FLJ18227, FLJ93013, FLJ99884
EC.number	1.3.99.3

DNA

TYPE	functioning gene
STRUCTURE	39.31 kb     12 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 - 2615 isoform a 43.6 421 - O'Reilly (2005) variant 3 13 - 2627 43.64 425 - O'Reilly (2005)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly Muscular striatum cardiac   highly Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal all-alpha domain
	transmembrane domain
	C terminal all-alpha, four helical up-and-down bundle

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

acyl-CoA dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION

acyl-CoA dehydrogenase, medium chain (C6-C12), fatty acid beta-oxidation, first step, transferring an electron to ETF

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic , lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	FAD+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ACADM

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS