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FLASH GENE
Symbol ACAD8 contributors: - updated : 09-03-2007
HGNC name acyl-Coenzyme A dehydrogenase family, member 8
HGNC id 87
Corresponding disease
ACAD8D Acyl-CoA dehydrogenase deficiency, member 8
Location 11q25      Physical location : 134.123.433 - 134.135.744
Synonym name
  • activator- recruited cofactor 42 kDa component
  • isobutyryl-CoA dehydrogenase
  • Synonym symbol(s) ACAD-8, FLJ22590, ARC42
    EC.number 1.3.99.-
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveinterstitial   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer tetramer
    HOMOLOGY
    interspecies ortholog to murine Acad8
    Homologene
    FAMILY acyl-CoA dehydrogenase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a role in transcriptional coactivation within the ARC complex
  • isobutyryl-CoA dehydrogenase that functions in valine catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid , energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • FAD
  • ETF electron acceptor
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACAD8D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS