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FLASH GENE
Symbol ABLIM1 contributors: - updated : 26-09-2006
HGNC name actin binding LIM protein 1
HGNC id 78
Location 10q25      Physical location : 116.190.869 - 116.444.414
Synonym name limatin
Synonym symbol(s) LIMAB1, KIAA0059, ABLIM, LIMATIN, MGC1224, DKFZp781D1048
DNA
TYPE functioning gene
STRUCTURE 227.00 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure high density of brain and CNS specific transcription factor' binding sites in the promoter region
MAPPING cloned Y linked N status provisional
Physical map
KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1 MGC35062 10q26.11-q26.12 Similar to RIKEN cDNA 1700011F14 gene LOC119548 10q26.12 hypothetical protein LOC119548 PNLIP 10q24-q26 pancreatic lipase PNLIPRP1 10q26.12 pancreatic lipase-related protein 1 PNLIPRP2 10q26.12 pancreatic lipase-related protein 2 MGC33547 10q26.12 hypothetical protein MGC33547 HSPA12A  heat shock 70kDa protein 12A LOC387712 10 similar to RIKEN cDNA 6430537H07 gene KIAA1598 10q26.12 KIAA1598 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 7597 87 778 - -
- - 7704 - 746 - -
- splicing 7620 - 718 - -
differs from variant 1 in the 5'UTRand in the coding region
- - 6850 - 455 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four N terminal cysteine-rich LIM/double zinc finger motifs
  • a C terminal end homolog to actin-bundling domain of erythrocyte cytoskeleton (dematine like/villin headpiece domain (VHP))domain)
  • HOMOLOGY
    interspecies homolog to murine Ablim1
    intraspecies homolog to DEMATIN
    homolog to dematin
    Homologene
    FAMILY LIM protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • putatively bridging the actin-based cytoskeleton with an array of potential LIM protein-binding partners
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text regulation of actin reorganization by phosphorylation regulated mechanism
  • involved in axon guidance
  • PATHWAY
    metabolism
    signaling sensory transduction/vision
    photoreception
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F-actin
  • binary protein prtein interactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS