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FLASH GENE
Symbol ABHD6 contributors: - updated : 29-09-2007
HGNC name abhydrolase domain containing 6
HGNC id 21398
Location 3p14.3      Physical location : 58.223.258 - 58.280.459
Synonym name
  • lipase protein
  • 2-arachidonoylglycerol hydrolase
  • monoacylglycerol lipase ABHD6
  • Synonym symbol(s) LOC57406
    EC.number 3.1.1.23
    DNA
    TYPE functioning gene
    STRUCTURE 57.20 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2413 38.2 337 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Lymphoid/Immunespleen   highly
    Nervousbrainlimbic systemhippocampus  
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsensoryolfactory  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha/beta hydrolase fold motif
  • HOMOLOGY
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having hydrolase activity
  • with MGLL, and ABHD12, display distinct subcellular distributions, suggesting that they may control different pools of 2-AG (2-arachidonoylglycerol) in the nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS