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FLASH GENE
Symbol ABHD16A contributors: mct - updated : 20-10-2021
HGNC name abhydrolase domain containing 16A,
HGNC id 13921
Corresponding disease
SPG85 spastic paraplegia 85
Location 6p21.33      Physical location : -
Synonym name
  • lymphocyte antigen B-associated transcript 5
  • DNA segment, single copy, probe K17B
  • protein G5
  • HLA-B associated transcript 5
  • Synonym symbol(s) D6S82E, G5, BAT5, NG26, PP199, hBAT5
    EC.number 3.1.1.23
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 16.35 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located localized in the vicinity of alpha and beta TNF genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 1977 63.11 558 - 2021 33763481
    18 - 2025 - 525 - 2021 33763481
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   moderately
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Reproductivefemale systemplacenta  moderately
     female systemuteruscervix predominantly
     female systemovary  moderately
    Urinarykidney   highly
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Bat5 (95.3pc)
    ortholog to murine Bat5 (96.1pc)
    Homologene
    FAMILY
  • family of metabolic serine hydrolases
  • ABHD superfamily of proteins that share an alph/beta-hydrolase fold
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • supposed to be involved in some aspects of immunity
  • is a genuine lipase with preference for long-chain unsaturated monoacylglycerols (MAGs)
  • has acylglycerol monoacylglycerols (MAGs) lipase and phosphatidylserine lipase activities
  • metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade Lysophosphatidylserine (lyso-PS), respectively in the brain
  • pophosphatidylserine lipase ABHD16A is an endoplasmic reticulum-localized enzyme, an organelle intricately regulating cellular PS levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFITM3 interacts with ABHD16A, following which it can better inhibit the replication of influenza virus and the inflammatory response caused by the disease process
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG85
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS