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FLASH GENE
Symbol ABCG4 contributors: mct - updated : 29-08-2018
HGNC name ATP-binding cassette, sub-family G (WHITE), member 4
HGNC id 13884
Location 11q23.3      Physical location : 119.019.749 - 119.033.372
Synonym name putative ABC transporter
Synonym symbol(s) WHITE2
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - [D11S1347 - APOC3 APOC3 - APOA4 - APOA1 - D11S939 - ABCG4 - D11S924 - HYALP - D11S933 ] - qter
Authors Annilo (01)
Physical map
DDX6 11q23.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 LOC338656 11q23.3 similar to protein phosphatase 2A inhibitor-2 I-2PP2A BLR1 11q23.3 Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) BCL9L 11q23.3 B-cell CLL/lymphoma 9-like UPK2 11q23 uroplakin 2 LOC283150 11q23.3 hypothetical protein LOC283150 DLNB14 11q23.3 similar to DLNB14 RPS25 11q23.3 ribosomal protein S25 TRAPPC4 11q23.3 trafficking protein particle complex 4 SLC37A4 11q23.3 solute carrier family 37 (glycerol-6-phosphate transporter), member 4 HYOU1 11q23.1-q23.3 hypoxia up-regulated 1 VPS11 11q23 vacuolar protein sorting 11 (yeast) HMBS 11q23.3 hydroxymethylbilane synthase H2AFX 11q23.3 H2A histone family, member X DPAGT1 11q23.3 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) KIAA0285 11q23.3 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) MIZF 11q23.3 MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein ABCG4 11q23.3 ATP-binding cassette, sub-family G (WHITE), member 4 NOD9 11q23.3 NOD9 protein PDZK2 11q23.3 PDZ domain containing 2 LOC387812 11 LOC387812 CBL 11q23.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence MCAM 11q23.3 melanoma cell adhesion molecule RNF26 11q23 ring finger protein 26 C1QTNF5 11q23.3 C1q and tumor necrosis factor related protein 5 MFRP 11q23 membrane frizzled-related protein USP2 11q23.3 ubiquitin specific protease 2 LOC94105 11q22.3-q23 Thy-1 co-transcribed THY1 11q23.3 Thy-1 cell surface antigen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3874 71 646 - Annilo, Vaughan (2006)
- - - - - lung Annilo (2001)
this variant is probably very rare
- - - - - highly expressed in thymus Annilo (2001)
- - - - - highly expressed in thymus Annilo (2001)
- - - - - thymus Annilo (2001)
- - - - - thymus Annilo (2001)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Nervousbrain   highly Mus musculusFetal
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single ATP-binding domain
  • a cluster of six transmembrane-spanning domains providing substrate specificity
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila Atet protein
    ortholog to murine Abcg4
    intraspecies homolog to ABCG1 protein
    Homologene
    FAMILY
  • ABC transporter family
  • ABCG (White) subfamily
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • hydrolyzes ATP
  • putatively involved in macrophage lipid homeostasis
  • may involve cholesterol transport
  • ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text
  • potential role in cholesterol transport processes in brain
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATP binding
  • interacting with ABCG1, in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles
  • HUWE1 and NEDD4, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters
  • cell & other
    REGULATION
    induced by oxysterols and retinoids
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS