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FLASH GENE
Symbol ABCF1 contributors: mct/npt - updated : 13-01-2010
HGNC name ATP-binding cassette, sub-family F (GCN20), member 1
HGNC id 70
Location 6p21.33      Physical location : 1.832.075 - 30.559.307
Synonym name
  • yeast GCN20 transcriptional regulator related
  • ATP-binding cassette 50 (TNF-alpha stimulated)
  • TNF-alpha-stimulated ABC protein
  • Synonym symbol(s) ABC50, GCN20R, ABC27, EST123147
    DNA
    TYPE functioning gene
    STRUCTURE 20.14 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 3474 - 845 - Paytubi (2009)
    24 - 3360 - 807 - Paytubi (2009)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     synoviocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    Text induced by TNFA (in synoviocytes)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal domain that differs most markedly from other ABC proteins, and cannot bind to ribosomes by itself, but it can in conjunction with one of the nucleotide-binding domains (Paytubi 2009)
  • Walker A motifs are required for ATP binding but not for ribosome binding
  • two ATP-binding cassettes (also termed nucleotide-binding domains (NBDs)
  • a yeast homolog cluster-specific motif type IV
  • a nuclear localization signal (NLS)
  • two ABC transporter family signature motifs
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Abcf1
    Homologene
    FAMILY
  • ATP binding cassette superfamily
  • subfamily F (GCN20)
  • CATEGORY immunity/defense , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    text located in the cytoplasm and nucleoplasm but not in the nucleolus (Paytubi 2009)
    basic FUNCTION
  • involved in translation of mRNA
  • potentially involved in inflammatory process
  • third ABC protein with a likely function in mRNA translation, which associates with eIF2 and with ribosomes (Tyzack 2000)
  • ABC (ATP-binding cassette) protein which, unlike most ABC proteins, lacks membrane-spanning domains (Paytubi 2009)
  • plays a key role in translation initiation, play roles in the biogenesis, function, or control of the translational machinery of eukaryotic cells and has functions that are distinct from those of other non-membrane ABC proteins (Paytubi 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with EIF2 (eukaryotic initiation factor 2), a protein that plays a key role in translation initiation and in its control, and in regulation of ribosomes (Paytubi 2009)
  • associates with the ribosome and co-sediments in sucrose gradients with the 40 and 60 S ribosomal subunits (Tyzack 2000)
  • ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
  • cell & other
    REGULATION
    induced by TNFA
    Other phosphorylated at two sites by CK2 (Paytubi 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS