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FLASH GENE
Symbol ABCE1 contributors: mct - updated : 17-01-2017
HGNC name ATP-binding cassette, sub-family E (OABP), member 1
HGNC id 69
Location 4q31.21      Physical location : 146.019.155 - 146.050.675
Synonym name
  • oligoisoadenylate
  • ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor
  • RNase L inhibitor R
  • Synonym symbol(s) RLI, RNS4I, RNASELI, OABP, ABC38, RNASEL1, RLI1, HP68
    DNA
    TYPE functioning gene
    STRUCTURE 31.52 kb     18 Exon(s)    one Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 4194 - 599 - 2007 17355973
    18 - 4191 - 599 - 2007 17355973
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestivepharynx   highly
     salivary gland   highly
    Reproductivefemale systemovary   
     male systemtestis   
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a unique N-terminal region with eight conserved cysteines, predicted to coordinate iron-sulfur clusters (N-terminal Fe-S binding domain)
  • eight cysteine, histidine and lysine residues
  • twin ABC ATPase domains, which are arranged in a head-to-tail orientation via a flexible linker and hinge region
  • two essential diamagnetic [4Fe-4S]2+ clusters
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Abce1
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily E (OABP)
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a critical role for proper assembly of the HIV-1 capsid
  • playing a role in RNase L inhibition, human immunodeficiency virus (HIV1)capsid maturation, translation initiation, and ribosome biosynthesis
  • role in eukaryotic translation has been linked to several stages during protein synthesis, including initiation and most recently termination and ribosome recycling
  • required for the assembly of the HIV and SIV gag polypeptides
  • promotes eukaryotic ribosomal recycling over a wide range of Mg(2+) concentrations
  • play an important role in the pathogenesis of human small cell lung cancer cell
  • essential and highly conserved protein that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis
  • its function is a primary target of ROS action
  • is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of RNASEL
  • ribosome-recycling factor important for translation termination in mammalian cells
  • is crucial for ribosome recycling and controls ribosome homeostasis
  • is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression
  • erythroid cells and platelets ribosomes accumulate as a result of the natural loss of the ribosome recycling factor ABCE1 during terminal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Rnase4 inhibitor, 2', 5'-oligoisoadenylate dependent, interferon regulated pathway
    a component
  • ABCE1/Pelota/HBS1L also dissociated vacant 80S ribosomes, which stimulated 48S complex formation, suggesting that Pelota/HBS1L have an additional role outside of stable secondary structures (NGD)
  • heterodimer with RNASEL, ABCE1 protein inhibits the IFN-depended RNASEL system and regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis
  • INTERACTION
    DNA
    RNA
    small molecule playing a role in RNase L inhibition, human immunodeficiency virus (HIV) capsid maturation, translation initiation, and ribosome biosynthesis
    protein
  • interact with translation initiation factors, eIF2, eIF3, eIF5, the 40 S ribosomal subunit, and several ribosomal RNAs
  • UBASH3A bind to ABCE1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion
  • interacting with PELO/HBS1L (Pelota/HBS1L induced dissociation of elongation complexes and release of peptidyl-tRNA, but only in the presence of ABCE1)
  • RNASEL inhibitor, ABCE1 is currently recognized as an essential translation factor involved in several stages of eukaryotic translation and ribosome biogenesis
  • ABCE1 interacts with the cytoskeleton protein actin and increases cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is correlated with aggressive growth and metastasis in lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may be used as a potential target of gene therapy for small cell lung cancer
    ANIMAL & CELL MODELS