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FLASH GENE
Symbol ABCC5 contributors: - updated : 20-09-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
HGNC id 56
Location 3q27      Physical location : 183.637.725 - 183.735.727
Synonym name
  • multidrug resistance associated protein 5
  • canalicular multispecific organic anion transporter C
  • Synonym symbol(s) MRP5, MOATC, SMRP, ABC33, MOAT-C, pABC11
    DNA
    TYPE functioning gene
    STRUCTURE 97.00 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5851 - 1437 - Wu
    - - 2007 - 208 - Wu
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouth   highly
    Nervousbrain    
     nervecranial nerve  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two ATP binding, each containing highly conserved Walker motifs
  • two transmembrane (2TM) domains (2 x 6 segments)
  • HOMOLOGY
    interspecies homolog to C.elegans F14F4.3B
    Homologene
    FAMILY
  • ATP binding cassette superfamily, subfamily C (CFTR/MRP)
  • CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative glutathione (GSH) conjugate (GS-x) pump or canalicutar multispecific anion transporter, involved in drug resistance (thiopurine to potecan, doxorubicin)
  • acting as a multispecific organic anion pump which can transport nucleotide analogs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS