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FLASH GENE
Symbol ABCC3 contributors: - updated : 22-03-2005
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 3
HGNC id 54
Location 17q21.3      Physical location : 48.712.217 - 48.769.062
Synonym name
  • canalicular multispecific organic anion transporter 2, rat ortholog
  • multi-specific organic anion transporter-D
  • multidrug resistance-associated protein 3
  • Synonym symbol(s) MRP3, CMOAT2, ABC31, MOAT-D
    DNA
    TYPE functioning gene
    STRUCTURE 57.00 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein MYST2 17q21.32 MYST histone acetyltransferase 2 TAC4 17 tachykinin 4 (hemokinin) LOC124865 17q21.33 similar to ribosomal protein P0-like protein; 60S acidic ribosomal protein PO; ribosomal protein, large, P0-like DLX4 17q21-q22 distal-less homeobox 4 DLX3 17q21.3-q22 distal-less homeo box 3 ITGA3 17q22-q23 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) PDK2 17q21.3 pyruvate dehydrogenase kinase, isoenzyme 2 LOC201191 17q21.33 hypothetical protein LOC201191 PPP1R9B 17q21-q22 protein phosphatase 1, regulatory subunit 9B, spinophilin SGCA 17q21 sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) HILS1 17q21.33 spermatid-specific linker histone H1-like protein COL1A1 17q21.31-q22.15 collagen, type I, alpha 1 FLJ33318 17q21.33 hypothetical protein FLJ33318 XYLT2 17q21.3-17q22 xylosyltransferase II MRPL27 17q21.3-q22 mitochondrial ribosomal protein L27 FLJ31364 PRO1855 17q21.33 hypothetical protein PRO1855 FLJ20920 17q21.33 hypothetical protein FLJ20920 MRPS21P9 17q21 mitochondrial ribosomal protein S21 pseudogene 9 CHAD 17q21.33 chondroadherin FLJ11164 17q21.33 hypothetical protein FLJ11164 DKFZp434N1415 17q21.33 Mycbp-associated protein EPN3 17q24.1 epsin 3 FLJ21347 17q21.33 hypothetical protein FLJ21347 LOC253962 17q21.33 hypothetical protein LOC253962 CACNA1G 17q22 calcium channel, voltage-dependent, alpha 1G subunit ABCC3 17q21.3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 MGC15396 17q21.33 hypothetical protein MGC15396 LUC7A 17q21 cisplatin resistance-associated overexpressed protein OA48-18 17q21.33 acid-inducible phosphoprotein FLJ20694 17q21.33 hypothetical protein FLJ20694 LOC390801 17 similar to S100 calcium-binding protein A10; S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); annexin II ligand, calpactin I, light polypeptide WFIKKNRP 17q21.33 WFIKKN-related protein LOC390802 17 similar to ribosomal protein L5; 60S ribosomal protein L5 TOB1 17q21 transducer of ERBB2, 1 SPAG9 17q21.31 sperm associated antigen 9 NME1 17q21.31 non-metastatic cells 1, protein (NM23A) expressed in NME2 17q21.31 non-metastatic cells 2, protein (NM23B) expressed in MBTD1 17q24.1 mbt domain containing 1 CGI-48 17q21.33 CGI-48 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5170 - 1527 - Kool
    - splicing 2320 - 1238 - Kool
    - splicing 5380 - 510 - Kool
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     liver    
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines hepatocellular carcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tandemly repeated polytopic membrane-spanning domains (MSDs) typical of ABC transporters, and a third NH(2)-terminal MSD
  • two ATP binding (nucleotide binding fold) each containing highly conserved Walker motifs
  • three transmembrane (3TM) domains (3 x 6 segments)
  • HOMOLOGY
    Homologene
    FAMILY ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3
    CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral membrane of cholangiocytes
    basic FUNCTION
  • ABC transporter,traffic ATPase,involved in the adrenal glands
  • biliary and intestinal excretion of organic anions and drugs (methotrexate,etoposide)
  • ATP-dependent transporter of bile salts
  • inducible transporter in the liver,under cholestic conditions
  • may contribute as a plausible bile salt-exporting transporter to the enterohepatic circulation of bile salts
  • having specific biologic functions in epidermal lipid reorganization during terminal keratinocyte differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by chenodeoxycholic acid (CDCA), in a dose- and time-dependent manner
    Other inverse of ABCC2
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS