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FLASH GENE
Symbol ABCC2 contributors: mct - updated : 13-03-2009
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 2
HGNC id 53
Corresponding disease
DJS Dubin-Johnson syndrome
Location 10q24.2      Physical location : 101.542.462 - 101.611.662
Synonym name
  • canalicular multispecific organic anion transporter 1, rat ortholog
  • canalicular multidrug resistance protein
  • multidrug resistance protein 2
  • Synonym symbol(s) KIAA1010, MRP2, CMOAT, ABC30, DJS, CMOAT1, CMRP
    DNA
    TYPE functioning gene
    STRUCTURE 69.20 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure ARE (antioxidant-response element) in the promoter
    MAPPING cloned Y linked N status confirmed
    Physical map
    CNNM1 10q24.33 cyclin M1 GOT1 10q24 glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) NKX2-3 10q24.33 NK2 transcription factor related, locus 3 (Drosophila) SLC25A28 10q24 solute carrier family 25, member 28 LALP1 10q23-q24 solute carrier family 25, member 28 COX15 10q24 COX15 homolog, cytochrome c oxidase assembly protein (yeast) CGI-32 10q24.31 CGI-32 protein ABCC2 10q24 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 KIAA1010 10q25.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 CPN1 10q24.31 carboxypeptidase N, polypeptide 1, 50kD KEO4 CHUK 10q24-q25 conserved helix-loop-helix ubiquitous kinase FLJ10998 10q24.31 hypothetical protein FLJ10998 MGC10120 10q24.31 hypothetical protein MGC10120 PKD2L1 10q24-q25 polycystic kidney disease 2-like 1 SCD 10q23-q24 stearoyl-CoA desaturase (delta-9-desaturase) LOC90271 10q24.31 hypothetical protein LOC90271 WNT8B 10q24 wingless-type MMTV integration site family, member 8B SEC31L2 10q24.32 SEC31-like 2 (S. cerevisiae) NDUFB8 10q23.2-q23.33 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa HIF1AN 10q24 hypoxia-inducible factor 1, alpha subunit inhibitor PAX2 10q22.1-q24.3 paired box gene 2 C10orf6 10q24.31 chromosome 10 open reading frame 6 SEMA4G 10q24.2 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G MRPL43 10q24.1-q24.3 mitochondrial ribosomal protein L43 PEO1 KIAA1813 10q24 KIAA1813 protein FLJ23209 10q24.32 hypothetical protein FLJ23209
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 5051 174.1 1545 - 2008 19038257
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte Homo sapiens
    cell lineage
    cell lines hepatocellular carcinoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tandemly repeated polytopic membrane-spanning domains (MSDs) typical of ABC transporters
  • a third NH(2)-terminal MSD
  • two ATP binding cassette (nucleotide binding fold) each containing three highly conserved motifs in ABC transporter Walker A, B, C
  • three transmembrane (3TM) domains (3 x 6 segments), with alternative splicing
  • the transmembrane domains involved in substrate recognition/transport
  • a seven-amino-acid extension at its C-terminus with the last three amino acids (TKF) comprising a PDZ-interacting motif, a class I PDZ-binding motif STKF
  • cytoplasmic loop 3 with a lysine-rich element that is essential for apical targeting, is important for interaction with both the glutathione and glucuronide conjugates
  • HOMOLOGY
    interspecies ortholog to rattus Abcc2
    homolog to murine Abcc2
    Homologene
    FAMILY
  • ABC transporter superfamily
  • ABCC family
  • conjugate transporter subfamily
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text canalicular apical membrane of hepatocyte and kidney proximal tubule
    basic FUNCTION
  • ABC transporter, traffic ATPase exporting anionic conjugates across the apical membrane of polarized cells
  • excretes amphiphilic organic anions into bile
  • glutathione (GSH) conjugate (GS-x) pump or canalicular multispecific anion transporter, cellular cisplatin transporter
  • having specific biologic functions in epidermal lipid reorganization during terminal keratinocyte differentiation
  • localized at the canalicular membrane of hepatocytes and playing an important role in bile formation and detoxification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text biliary transport
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds NFE2L2 (regulation of ABCC2 expression via the ARE element located at the proximal region of the promoter in response to exposure to xenobiotics)
  • can bind to SLC9A3R1, a PDZ protein that cross-links membrane proteins to actin filaments
  • cell & other
  • interaction with cholesterol (similarly affects the transport function of ABCC2 by interacting with its putative substrate-binding site and transport substrates)
  • REGULATION
    Other inverse of ABCC3
    ASSOCIATED DISORDERS
    corresponding disease(s) DJS
    Susceptibility
  • to nonalcoholic fatty liver disease
  • to intrahepatic cholestasis of pregnancy (ICP)
  • Variant & Polymorphism other
  • variant for rs17222723 and rs8187710 increasing the risk of nonalcoholic fatty liver disease
  • association between the rs3740066 in exon 28 of ABCC2 gene and ICP
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS