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FLASH GENE
Symbol ABCC10 contributors: - updated : 10-06-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 10
HGNC id 52
Location 6p21.2-p21.1      Physical location : 43.399.488 - 43.418.163
Synonym name
  • multidrug resistance-associated protein 7
  • Synonym symbol(s) MRP7, SIMRP7
    DNA
    TYPE functioning gene
    STRUCTURE 22.00 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • promoter activity relied upon a proximal segment of the 5' flanking region 169 to 257 nt in length bearing an E2F site acting cooperatively with two closely positioned Sp1 sites
  • two additional Sp1 sites further downstream were of secondary importance
  • MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two ATP binding domains
  • three transmembrane (3TM) domains (transmembrane helices arranged in three membrane spanning domains)
  • HOMOLOGY
    interspecies ortholog to murine Abcc10
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily C (CFTR/MRP)
    CATEGORY signaling , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION involved in multi-drug resistance
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text amphipathic anions transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS