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FLASH GENE
Symbol ABCB9 contributors: mct/npt - updated : 01-02-2008
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 9
HGNC id 50
Location 12q23.31      Physical location : 123.413.539 - 123.459.752
Synonym name
  • multidrug resistance 4
  • TAP-like
  • ABC transporter 9 protein
    • Synonym symbol(s) MDR4, TAPL, KIAA1520, EST122234
    DNA
    TYPE functioning gene
    STRUCTURE 37.52 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    text structure 60bp upstream sequence containing two GC-boxes from the transcriptional start site confers basal promoter activity
    MAPPING cloned Y linked N status provisional
    Map cen - D12S366 - RPLP0 - D12S86 - D12S349 - D12S321 - ACADS ACADS - RSN - ABCB9 - D12S342 - D12S340 - qter
    Authors Gene Map (98), LDB (99)
    Physical map
    MGC33630 12q24.31 hypothetical protein MGC33630 BCL7A 12q24.13 B-cell CLL/lymphoma 7A MONDOA 12q21.31 Mlx interactor MGC35140 12q24.31 hypothetical protein MGC35140 B3GNT4 12q24 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 DIABLO 12q24.1-q24.31 diablo homolog (Drosophila) VPS33A 12q24.31 vacuolar protein sorting 33A (yeast) RSN 12q24.3 restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) RPL21P1 12q24.2-q24.3 ribosomal protein L21 pseudogene 1 DKFZp434E2220 12q24.31 hypothetical protein DKFZp434E2220 FLJ11021 12q24.31 similar to splicing factor, arginine/serine-rich 4 KNTC1 12q24.31 kinetochore associated 1 HM74a 12q24.31 G protein-coupled receptor HM74a HM74 12q24.31 G protein-coupled receptor HM74a GPR81 12q24.3 G protein-coupled receptor 81 DENR 12q24.31 density-regulated protein TSP-NY 12q24.31 testis-specific protein TSP-NY HIP1R 12q24 huntingtin interacting protein-1-related FLJ12750 12q24.31 hypothetical protein FLJ12750 ABCB9 12q24.31-q24.32 ATP-binding cassette, sub-family B (MDR/TAP), member 9 FLJ13491 12q24.31 hypothetical protein FLJ13491 ARL6IP4 12q24.31 ADP-ribosylation-like factor 6 interacting protein 4 PITPNM2 12q24.31 phosphatidylinositol transfer protein, membrane-associated 2 FLJ13769 12q24.31 hypothetical protein FLJ13769 MPHOSPH9 12q24.31 M-phase phosphoprotein 9 FLJ38663 12q24.31 hypothetical protein FLJ38663 CDK2AP1 12q24.31 CDK2-associated protein 1 SBNO1 12q24.31 sno, strawberry notch homolog 1 (Drosophila) LOC387893 12 similar to SET domain-containing protein 8 MGC7036 12q24.31 hypothetical protein MGC7036 RNP24 12q24.31 coated vesicle membrane protein DDX55 12q24.31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 EIF2B1 12q24.2-q24.31 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa GTF2H3 12q24.31 general transcription factor IIH, polypeptide 3, 34kDa FLJ12975 12q24.31 hypothetical protein FLJ12975 ATP6V0A2 12q24.31 ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 DNAH10 13q14 dynein, axonemal, heavy polypeptide 10 FLJ22471 12q24.31 limkain beta 2 DKFZp761B128 12q24.31 hypothetical protein DKFZp761B128
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3546 - 766 testis Allikmets, Wolters, Ohashi-Kobayashi (2006)
    deleted of last pair of TM segments
    11 splicing 3417 - 723 several tissues Allikmets, Ohashi-Kobayashi (2006)
    - splicing 2588 - 683 - Kobayashi
  • also called TAPL12B
  • shorter carboxyl terminal amino acid sequences than 12A
    • 12 splicing 3814 - 766 - Kobayashi, Ohashi-Kobayashi (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   moderately
     spinal cord    
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal four transmembrane helices would be separately located from the core domain helices and may well interact with cellular components required for its lysosomal targeting (Kamakura 2008)
  • one ATP binding
  • one transmembrane (1TM) domain with ten potential transmembrane helices followed by a conserved ABC region
  • a nucleotide binding domain with WALKER motif
  • a ABC transporter domain
  • a peptidase C39 domain
    • HOMOLOGY
    interspecies homolog to rattus abcb9
    homolog to murine Abcb9
    homolog to murine Tapl
    intraspecies homolog to ABCB2,ABCB3
    Homologene
    FAMILY
  • ATP binding cassette superfamily
  • subfamily B (MDR/TAP)
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text detected in the lysosomal compartment co-localizing with the lysosome-associated membrane protein LAMP2, and LAMP1
    basic FUNCTION
  • half-ABC transporter, traffic ATPase, may play a role in lysosomes
  • involved in multidrug resistance as well as antigen presentation
  • may be the key link missing in the chaperone-mediated autophagy and a novel route discharging cytosolic antigens in lysosomal compartments induced in professional antigen-presenting cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by during differentiation of monocytes to dendritic cells and to macrophages
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS