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FLASH GENE
Symbol ABCB10 contributors: mct/npt - updated : 21-03-2019
HGNC name ATP-binding cassette, sub-family B (MDR/TAP), member 10
HGNC id 41
Location 1q42.13      Physical location : 229.652.329 - 229.694.442
Synonym name
  • mitochondrial ABC protein 2
  • ATP-binding cassette sub-family B member 10, mitochondrial
  • ABC transporter 10 protein
  • clone 06B092, murine multidrug resistance 1 homolog
  • Synonym symbol(s) INFA, M-ABC2, MTABC2, EST20237, ABC06B092
    DNA
    TYPE functioning gene
    STRUCTURE 42.11 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U LOC388751 1 LOC388751 RAB4A 1q42-q43 RAB4A, member RAS oncogene family SPHAR 1q42.11-q42.3 S-phase response (cyclin-related) LOC126731 1q42.13 LOC126731 ACTA1 1q42.13-q42.2 actin, alpha 1, skeletal muscle NUP133 1q42.13 nucleoporin 133kDa ABCB10 1q42 ATP-binding cassette, sub-family B (MDR/TAP), member 10 TAF5L 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa KIAA0133 1q42.13 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC391177 1 similar to HMG-1 LOC388752 1 LOC388752 GALNT2 1q41-q42 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) PGBD5 1q42.13 piggyBac transposable element derived 5
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3861 79 738 - Graf (2004)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal unusually long 105-amino acid mitochondrial targeting presequence (mTP)
  • two ATP binding and two transmembrane domains (2x6 segments)
  • mono polymer homomer , dimer , oligo
    HOMOLOGY
    interspecies homolog to E.coli INFA
    Homologene
    FAMILY
  • ABC transporter superfamily
  • ABCB family
  • mitochondrial peptide exporter subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • mitochondrial inner membrane erythroid transporter involved in heme biosynthesis
  • may be having a physiological role in the antigen processing
  • mitochondrial inner membrane ATP-binding cassette transporter highly induced during erythroid maturation in hematopoietic tissues (Chen 2009)
  • half-transporter functioning as a homodimer and required for SLC25A37 protein stability and mitochondrial iron import in erythroid cells (Chen 2009)
  • critical role for ABCB10 in heme biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FECH forms an oligomeric complex with SLC25A37 and ABCB10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis
  • a dimeric FECH physically bridged ABCB7 and ABCB10 homodimers by binding near the NBDs of each ABC transporter
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with SLC25A37 to enhance its protein stability and, as a consequence, increase iron import into the mitochondria (Chen 2009)
  • SLC25A37 interacts with ABCB10 to enhance mitochondrial iron importation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS