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FLASH GENE
Symbol ABCA6 contributors: mct/pgu - updated : 30-08-2008
HGNC name ATP-binding cassette, sub-family A (ABC1), member 6
HGNC id 36
Location 17q24.3      Physical location : 67.074.846 - 67.138.015
Synonym name
  • ABC transporter ABCA6
  • ATP-binding cassette A6
  • Synonym symbol(s) EST155051, FLJ43498
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered among 4 other ABC1 family members on 17q24
    STRUCTURE 63.17 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 - 5296 184 1617 - Kaminski (2001)
    - - - - 637 - Kaminski (2001)
    protein variant bearing the features of a truncated half-size transporter
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tandemly oriented subunits, each composed of a transmembrane domain
  • a nucleotide binding fold
  • HOMOLOGY
    intraspecies homolog to ABCA8
    Homologene
    FAMILY
  • ABC transporter superfamily
  • ABCA subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in macrophage lipid homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS