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FLASH GENE
Symbol ABCA10 contributors: - updated : 28-04-2005
HGNC name ATP-binding cassette, sub-family A (ABC1), member 10
HGNC id 30
Location 17q24      Physical location : 67.144.147 - 67.240.956
DNA
TYPE functioning gene
STRUCTURE 96.00 kb     40 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestine  highly
Endocrinepancreas    
Hearing/Equilibriumearinnercochlea  
Nervousbraindiencephalonhypothalamus highly
Reproductivefemale systemuterus   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text uterus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PEST sequence
  • the N-terminal transmembrane domain
  • HOMOLOGY
    intraspecies homolog to ABCA6, ABCA8, ABCA9
    Homologene
    FAMILY ABC transporter family, ABCA subfamily
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • influencing intracellular cholesterol transport
  • may be involved in macrophage lipid homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by cholesterol import into macrophages (cholesterol-responsive gene)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS