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FLASH GENE
Symbol AASDHPPT contributors: - updated : 01-06-2005
HGNC name aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
HGNC id 14235
Location 11q22      Physical location : 105.948.291 - 105.969.419
Synonym name
  • 4'-phosphopantetheinyl transferase
  • alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
  • Synonym symbol(s) LYS5, LYS5, CGI-80, AASD-PPT
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2900 36 309 - Praphanjhoj
    - - - 1500 - - testis Praphanjhoj
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    lacking peroxisomal targeting signal
    HOMOLOGY
    interspecies homolog to S. Cerevisiae Lys5
    Homologene
    FAMILY holo-acyl carrier protein synthase ACPS superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine
  • implicated in phosphopantetheinylation of the alpha-aminoadipate semialdehyde dehydrogenase involved in lysine catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    lysine catalytic pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS