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FLASH GENE
Symbol AASDHPPT contributors: - updated : 01-06-2005
HGNC name aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
HGNC id 14235
Location 11q22      Physical location : 105.948.291 - 105.969.419
Synonym name
  • 4'-phosphopantetheinyl transferase
  • alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
  • Synonym symbol(s) LYS5, LYS5, CGI-80, AASD-PPT
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SCDGF-B CASP12P1 11q22.3 caspase 12 pseudogene 1 CASP4 11q22.2-q22.3 caspase 4, apoptosis-related cysteine protease CASP5 11q22.2-q22.3 caspase 5, apoptosis-related cysteine protease CASP1 11q22.2-q22.3 caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) COP  clathrin-ordered protein ICEBERG 11q21-q22 ICEBERG caspase-1 inhibitor OR2AL1P 11q23.3 olfactory receptor, family 2, subfamily AL, member 1 pseudogene GRIA4 11q22.3 glutamate receptor, ionotrophic, AMPA 4 KIAA1826 11q22 KIAA1826 protein KBTBD3 11q22.3 kelch repeat and BTB (POZ) domain containing 3 AASDHPPT 11q22 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase GUCY1A2 11q21-q22 guanylate cyclase 1, soluble, alpha 2 LOC341230 11q23.1 similar to argininosuccinate synthetase FLJ32343 11q23.1 hypothetical protein FLJ32343 LOC91801 11q23.1 hypothetical protein BC015183 DKFZp547C176 11q23.1 hypothetical protein DKFZp547C176 SLN 11q22-q23 sarcolipin LOC203930 11q23.1 sorting nexin 7 pseudogene SLC35F2 11q23.1 solute carrier family 35, member F2 RAB39 11q22-q23 RAB39, member RAS oncogene family CUL5 11q22-q23 cullin 5 ACAT1 11q22.3 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) NPAT 11q22-q23 nuclear protein, ataxia-telangiectasia locus
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2900 36 309 - Praphanjhoj
    - - - 1500 - - testis Praphanjhoj
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    lacking peroxisomal targeting signal
    HOMOLOGY
    interspecies homolog to S. Cerevisiae Lys5
    Homologene
    FAMILY holo-acyl carrier protein synthase ACPS superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine
  • implicated in phosphopantetheinylation of the alpha-aminoadipate semialdehyde dehydrogenase involved in lysine catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    lysine catalytic pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS