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FLASH GENE
Symbol AASDH contributors: npt - updated : 25-06-2008
HGNC name aminoadipate-semialdehyde dehydrogenase
HGNC id 23993
Location 4q12      Physical location : 57.204.458 - 57.253.638
Synonym name
  • 2-aminoadipic 6-semialdehyde dehydrogenase
  • acyl-CoA synthetase family member 4
  • non-ribosomal peptide synthetase 1098
  • non-ribosomal peptide synthetase 998
  • Synonym symbol(s) NRPS998, LYS2, ACSF4, U26, NRPS1098
    EC.number 1.2.1.31, 6.2.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3573 - 1098 - Watkins (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Hearing/Equilibriumear   highly
    Nervousnerve   highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines colon adenocarcinoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an AMP-binding domain
  • a phosphopantetheine-binding domain
  • six PQQ-binding motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • acyl-coenzyme A synthetases family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • plays a unique role, directing the acyl-CoA product to a specific metabolic fate
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS