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FLASH GENE
Symbol AANAT contributors: mct - updated : 17-01-2009
HGNC name arylalkylamine N-acetyltransferase
HGNC id 19
Location 17q25.1      Physical location : 74.449.432 - 74.466.198
Synonym name serotonin N-acetyltransferase
Synonym symbol(s) AA-NAT, SNAT
EC.number 2.3.1.87
DNA
TYPE functioning gene
STRUCTURE 2.55 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
motif repetitive sequence   other
text structure SNP 263G/C in the transcription factor SP1 binding site
MAPPING cloned Y linked   status provisional
Map cen - D17S1817 - D17S801 - AANAT - D17S2245 - D17S2243 - qter
Physical map
UNC13D 17q25.3 unc-13 homolog D (C. elegans) WBP2 17q25 WW domain binding protein 2 TRIM47 17q24.q25 tripartite motif-containing 47 LOC201292 17q25.3 hypothetical protein LOC201292 MRPL38 17q23-q25 mitochondrial ribosomal protein L38 FBF-1 17q25.3 Fas binding protein 1 ACOX1 17q25.1 acyl-Coenzyme A oxidase 1, palmitoyl CDK3 17q25 cyclin-dependent kinase 3 EVPL 17q24.2-q24.3 envoplakin SRP68 17q25,1 signal recognition particle 68kDa GALR2 17q25.3 galanin receptor 2 LGICZ 17q25.3 ligand-gated ion channel subunit EXO70 17q25.3 ligand-gated ion channel subunit FOXJ1 17q forkhead box J1 KIAA1917 17q25.3 KIAA1917 protein MGC29814 17q25.3 hypothetical protein MGC29814 DKFZP434P0316 17q25.3 hypothetical protein DKFZp434P0316 PRPSAP1 17q24-q25 phosphoribosyl pyrophosphate synthetase-associated protein 1 SPHK1 17q25.2 sphingosine kinase 1 E2-230K 17q25.1 likely ortholog of mouse ubiquitin-conjugating enzyme E2-230K AANAT 17q25 arylalkylamine N-acetyltransferase FLJ22341 17q25.3 hypothetical protein FLJ22341 CYGB 17q25.3 cytoglobin STHM 17q25.3 cytoglobin SIAT7A 17q25.3 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) A FLJ46603 17q25.3 FLJ46603 protein PTDSR 17q25 phosphatidylserine receptor SFRS2 17q25.1 splicing factor, arginine/serine-rich 2 ET 17q25 hypothetical protein ET LOC283994 17q25.3 hypothetical protein LOC283994 GnT-IX 17q25.3 beta(1,6)-N-acetylglucosaminyltransferase V LOC388420 17 LOC388420
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1014 - 207 - Blomeke (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina    Homo sapiens
cell lineage
cell lines retinoblastoma cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • acetyltransferase family
  • AANAT subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • penultimate step in melatonin synthesis, controlling its circadian rhythm production
  • modulating the function of the circadian clock in the supra optical nucleus and influencing activity and sleep
  • catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis
  • controls daily changes in melatonin production by the pineal gland and thereby plays a unique role in biological timing in vertebrates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian
    PATHWAY
    metabolism hormone
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • controlling the circadian rhythm of melatonin production
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to delayed sleep phase syndrome
    Variant & Polymorphism SNP significantly associated with the delayed sleep phase syndrome
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS