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FLASH GENE
Symbol AAMDC contributors: mct - updated : 11-06-2021
HGNC name adipogenesis associated Mth938 domain containing
HGNC id 30205
Location 11q14.1      Physical location : -
Synonym name
  • PTD015 protein
  • hypothetical protein LOC28971
  • chromosome 11 open reading frame 67
  • Synonym symbol(s) MGC3367, FLJ21035, PTD015, C11orf67, CK067
    DNA
    TYPE functioning gene
    STRUCTURE 84.88 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 5995 - 137 - 2019 31116411
    6 - 5940 - 147 - 2019 31116411
    4 - 5798 - 79 - 2019 31116411
    6 - 5949 - 137 - 2019 31116411
    6 - 682 - 122 - 2019 31116411
    5 - 640 - 122 - 2019 31116411
    6 - 702 - 168 - 2019 31116411
    5 - 564 - 122 - 2019 31116411
    5 - 660 - 168 - 2019 31116411
    4 - 522 - 122 - 2019 31116411
    5 - 560 - 122 - 2019 31116411
    5 - 656 - 168 - 2019 31116411
    4 - 518 - 122 - 2019 31116411
    5 - 503 - 122 - 2019 31116411
    4 - 461 - 122 - 2019 31116411
    4 - 498 - 122 - 2019 31116411
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   highly
    Digestivepancreas exocrine   moderately
    Reproductivefemale systembreastmammary gland highly
     female systemovary  moderately
     male systemprostate  moderately
     male systemtestis  moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism
  • AAMDC-RABGAP1L complex could play a role in the regulation of vesicle trafficking, potentially altering the recycling of small G proteins and thus remodeling the cancer signaling network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AAMDC can interact with the RabGTPase-activating protein RABGAP1L, and AAMDC, RABGAP1L, and RAB7A colocalize in endolysosomes
  • cell & other
    REGULATION
    Other is post-transcriptionally regulated through alternative polyadenylation (APA) and microRNAs
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS