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FLASH GENE
Symbol AAK1 contributors: mct/npt/pgu - updated : 11-07-2009
HGNC name AP2 associated kinase 1
HGNC id 19679
Location 2p14      Physical location : 69.685.126 - 69.870.977
Synonym name
  • adaptor-associated kinase 1
  • eukaryotic protein kinase
  • Synonym symbol(s) KIAA1048, DKFZp686K16132, DKFZp686F03202, FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, MGC138170, MGC164568, MGC164570
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 185.85 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391382 2 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) C1D 2p13-p12 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) LOC116143 2p13.3 hypothetical protein BC014022 LOC56902 2p13.3 putatative 28 kDa protein PPP3R1 2p16-p15 protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) DKFZP566K1924 2p13.3 DKFZP566K1924 protein PLEK 2p14 pleckstrin LOC391383 2 similar to WD repeat domain 4 protein; WD repeat-containing protein 4 MGC47799 LOC391384 2 similar to KIAA0779 protein GPR73 2p14-p13.1 G protein-coupled receptor 73 KIAA0053 2p13.3 G protein-coupled receptor 73 BMP10 2p13.3 bone morphogenetic protein 10 LOC391385 2 similar to 18 kDa antrum mucosa protein; BRICHOS domain containing 1 GDDR 2p13.3 down-regulated in gastric cancer GDDR GKN1 2p13.3 gastrokine 1 ANTXR1 2p13.1 anthrax toxin receptor 1 GFPT1 2p13 glutamine-fructose-6-phosphate transaminase 1 HIRIP5 2p12 HIRA interacting protein 5 LOC388957 2 similar to expressed sequence C79663 LOC388958 2 hypothetical gene supported by AF090101 AAK1 2p24.3-p14 AP2 associated kinase 1 ANXA4 2p13 annexin A4 FLJ13057 2p13.3 hypothetical protein FLJ13057 similar to germ cell-less RY1 2p13.3 putative nucleic acid binding protein RY-1 MAD 2p12 MAX dimerization protein 1 FLJ25084 2p13.3 hypothetical protein FLJ25084 PCBP1 2p13-p12 poly(rC) binding protein 1 LOC151518 2p13.3 hypothetical LOC151518 MRPL36P1 2p13.2 hypothetical LOC151518 FLJ20558 2p13.3 hypothetical protein FLJ20558 TIA1 2p13 TIA1 cytotoxic granule-associated RNA binding protein PCYOX1 2p13.3 prenylcysteine oxidase 1 SNRPG 2p12 small nuclear ribonucleoprotein polypeptide G FLJ14668 2p13.3 hypothetical protein FLJ14668 TGFA 2p13 transforming growth factor, alpha ADD2 2p14-p13 adducin 2 (beta) CLECSF13 2p13.3 likely ortholog of mouse C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13 CD207 2p13 CD207 antigen, langerin VAX2 2p13.3 ventral anterior homeobox 2 ATP6V1B1 2p13 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1 (Renal tubular acidosis with deafness) FLJ12056 2p13.2 hypothetical protein FLJ12056 TEX261 2p13.2 testis expressed gene 261 LOC115131 2p13.2 similar to POSSIBLE GUSTATORY RECEPTOR CLONE PTE01 OR7E91P 2p12 olfactory receptor, family 7, subfamily E, member 91 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 21283 93.6 961 - 2007 17494869
    - - - - - - 2007 17494869
    contains an extended C-terminus that encodes an additional clathrin-binding domain (CBD2) consisting of multiple low-affinity interaction motifs
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • serine/threonine kinases family, Ark/Prk family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • as a regulator of clathrin-mediated endocytosis
  • may be specifically activated in coated pits to enhance cargo recruitment and efficient internalization
  • atypical kinase that is rate limited by its stable association with TFAP2A
  • functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome
  • key endocytic kinase, regulating NUMB endocytic activity
  • could play a positive role in early NOTCH1 endocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • interacting with NUMB (redistributes NUMB to perinuclear endosomes when overexpressed, while kinase depletion causes NUMB to accumulate at the plasma membrane)
  • directly interacts with the membrane-tethered active form of NOTCH1 released by metalloprotease cleavage
  • cell & other
    REGULATION
    activated by clathrin (efficient stimulation by clathrin involves multiple interactions between several domains on AAK1 and both heavy and light chains on clathrin)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS