Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AAK1 contributors: mct/npt/pgu - updated : 11-07-2009
HGNC name AP2 associated kinase 1
HGNC id 19679
Location 2p14      Physical location : 69.685.126 - 69.870.977
Synonym name
  • adaptor-associated kinase 1
  • eukaryotic protein kinase
    • Synonym symbol(s) KIAA1048, DKFZp686K16132, DKFZp686F03202, FLJ23712, FLJ25931, FLJ31060, FLJ42882, FLJ45252, MGC138170, MGC164568, MGC164570
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 185.85 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 21283 93.6 961 - 2007 17494869
    - - - - - - 2007 17494869
    contains an extended C-terminus that encodes an additional clathrin-binding domain (CBD2) consisting of multiple low-affinity interaction motifs
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • serine/threonine kinases family, Ark/Prk family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • as a regulator of clathrin-mediated endocytosis
  • may be specifically activated in coated pits to enhance cargo recruitment and efficient internalization
  • atypical kinase that is rate limited by its stable association with TFAP2A
  • functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome
  • key endocytic kinase, regulating NUMB endocytic activity
  • could play a positive role in early NOTCH1 endocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
    • protein
  • interacting with NUMB (redistributes NUMB to perinuclear endosomes when overexpressed, while kinase depletion causes NUMB to accumulate at the plasma membrane)
  • directly interacts with the membrane-tethered active form of NOTCH1 released by metalloprotease cleavage
    • cell & other
    REGULATION
    activated by clathrin (efficient stimulation by clathrin involves multiple interactions between several domains on AAK1 and both heavy and light chains on clathrin)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS