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FLASH GENE
Symbol AADAT contributors: - updated : 22-09-2007
HGNC name aminoadipate aminotransferase
HGNC id 17929
Location 4q32.2-q33      Physical location : 170.981.373 - 171.011.372
Synonym name
  • kynurenine aminotransferase II
  • L-kynurenine/alpha-aminoadipate aminotransferase
  • kynurenine--oxoglutarate aminotransferase II
  • Synonym symbol(s) KAT2, KATII
    EC.number 2.6.1.39, 2.6.1.7
    DNA
    TYPE functioning gene
    STRUCTURE 30.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2326 47 425 - Goh
    - - 2108 47 425 - Goh
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrinepancreas   lowly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systemuteruscervix lowly
     male systemtestis  highly
     male systemprostate  lowly
    Urinarykidney   lowly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • mitochondrial leader cleavage signal
  • pyridoxal-phosphate binding site
  • HOMOLOGY
    interspecies ortholog to murine Aadat
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS