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FLASH GENE
Symbol A2M contributors: - updated : 29-09-2006
HGNC name alpha-2-macroglobulin
HGNC id 7
Corresponding disease
A2M macroglobulin, alpha-2- deficiency
Location 12p13.31      Physical location : 9.220.303 - 9.268.558
Synonym name
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
  • alpha-2-M
  • Synonym symbol(s) A2MG, FWP007, S863-7, CPAMD5, DKFZp779B086
    DNA
    TYPE functioning gene
    STRUCTURE 48.26 kb     36 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D12S372 - A2M A2M - D12S391 - D12S320 - D12S373 - D12S1057 - D12S1042 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    36 - 4678 - 1474 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion plasma
    at STAGE
    physiological period embryo, fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • peptide stretch, called the 'bait region' with specific cleavage sites for different proteinases
  • secondary structure two pairs of disulfide linked chains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to murine A2m
    Homologene
    FAMILY
  • protease inhibitor I39 (alpha-2- macroglobulin) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    text serum
    basic FUNCTION
  • serum protease inhibitor mediating the clearance and degradation of A-beta, the major component of beta-amyloid deposits
  • protease inhibitor and cytokine transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text cytokine transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating to TGFBs and forming latent complexes
  • associating with PDGFVB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) A2M
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in clear cell renal carcinomas with poor outcome
    Susceptibility to Alzheimer disease (AD5)
    Variant & Polymorphism other
  • polymorphisms significantly associated with Alzheimer disease
  • A2M gene deletion associated with overweight and obesity in Thais
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS