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FLASH GENE
Symbol A2M last update : 29-09-2006
HGNC name alpha-2-macroglobulin
HGNC id 7
Corresponding disease
A2M macroglobulin, alpha-2- deficiency
Location 12p13.2-p13.1
Synonym symbol(s) A2MG, FWP007, S863-7, CPAMD5
DNA RNA EXP/sub-loc PROTEIN PATHOLOGY
DNA
TYPE functioning gene
STRUCTURE 48.00 kb     36 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D12S372 - A2M A2M - D12S391 - D12S320 - D12S373 - D12S1057 - D12S1042 - cen
Authors Blacker (98)
Physical map
SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein CLECSF6 12p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 LOC283321 12p13.31 hypothetical LOC283321 LOC387828 12 LOC387828 FLJ10408 12p13.31 hypothetical protein FLJ10408 LOC387829 12 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC387830 12 similar to CG7889-PA LOC93320 12p13.31 similar to Alkaline sphingomyelinase LOC387831 12 hypothetical gene supported by AK074886 LOC390287 12 hypothetical gene supported by AK122996 LOC390288 12 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC390289 12 similar to seven transmembrane helix receptor LOC341306 12p13.31 similar to 60S ribosomal protein L15 CLECSF8 12p13.31 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 CLECSF9 12p13.32 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 AICDA 12p13 activation-induced cytidine deaminase LOC94468 12p13.31 similar to 78 kDa gastrin-binding protein MAGP2 12p13.1-p12.2 similar to 78 kDa gastrin-binding protein KIAA1238 12p13.31 similar to 78 kDa gastrin-binding protein FLJ25179 12p13.31 hypothetical protein FLJ25179 PHC1 12p13 polyhomeotic-like 1 (Drosophila) M6PR 12p13.2 mannose-6-phosphate receptor (cation dependent) KLRG1 12p13.2-p13.1 killer cell lectin-like receptor subfamily G, member 1 LOC390290 12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC390291 12 similar to voltage-dependent anion channel isoform 2 MGC40170 12p13.31 hypothetical protein MGC40170 A2M 12p13.2-p13.1 alpha-2-macroglobulin PZP 12p13.2-p13.1 pregnancy-zone protein A2MP 12p13.2-p13.1 alpha-2-macroglobulin pseudogene PTMAP4 12p13.31 prothymosin, alpha pseudogene 4 (gene sequence 112) LOC387832 12 similar to helicase LOC387833 12 LOC387833 LOC387834 12 similar to DKFZp434C0631 protein LOC338812 12p13.31 similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11; DEAD/H box-11 (CHL1-related helicase gene-1); yeast CHL1 homolog LOC347939 12p13.31 similar to Ran-GTP binding protein; RanBP6 LOC390292 12 similar to ovomacroglobulin, ovostatin KLRB1 12p13.1-p12.3 killer cell lectin-like receptor subfamily B, member 1 LOC374443 12p13.31 CLR pseudogene LLT1 12p13 CLR pseudogene LOC387835 12 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 DCAL1 12p13.31 dendritic cell-associated lectin-1 CD69 12p13.2-p13.1 CD69 antigen (p60, early T-cell activation antigen) LOC390293 12 similar to ACRC protein; putative nuclear protein KLRF1 12p13.3-p13.2 killer cell lectin-like receptor subfamily F, member 1 CLECSF2 12p13.2-p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) LOC387836 12 similar to INPE5792 CLL-1 CLEC2 12p13.31 C-type lectin-like receptor-2 LOC387837 12 similar to macrophage antigen h LOC283420 12p13.31 similar to HEEE9341 CLEC1 12p13.31 C-type lectin-like receptor-1 LOC390294 12 similar to HNRPAB protein CLECSF12 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12 OLR1 12p13.1-p12.3 oxidised low density lipoprotein (lectin-like) receptor 1 FLJ31166 12p13.31 hypothetical protein FLJ31166
RNA
TRANSCRIPTS type messenger
EXPRESSION / SUBCELLULAR LOCALIZATION
EXPRESSION (based on citations)
constitutive of
   expressed in
organ(s)
SystemOrgan 1organ 2organ 3organ 4level
Digestiveliver    
tissue
SystemTissueS_TissueSs_Tissuelevel
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
physiological period embryo, fetal
Text liver
SUBCELLULAR LOCALIZATION extracellular
text
  • serum
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • peptide stretch, called the 'bait region' with specific cleavage sites for different proteinases
    • secondary structure two pairs of disulfide linked chains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies
     
    		 homolog to murine A2m
    intraspecies
     
    Homologene
    FAMILY protease inhibitor I39 (alpha-2- macroglobulin) family
    CATEGORY transport carrier
    basic FUNCTION
  • serum protease inhibitor mediating the clearance and degradation of A-beta, the major component of beta-amyloid deposits
  • protease inhibitor and cytokine transporter
    • implicated in a
    process
    cellular process
    physiological
    text cytokine transporter
    pathway
    metabolism
    signaling
    a component
    structural
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating to TGFBs and forming latent complexes
  • associating with PDGFVB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) A2M
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in clear cell renal carcinomas with poor outcome
    Susceptibility to Alzheimer disease (AD5)
    Variant & Polymorphism other
  • polymorphisms significantly associated with Alzheimer disease
  • A2M gene deletion associated with overweight and obesity in Thais
    • Candidate gene
    Therapy target
    animal or cellular model