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FLASH GENE
Symbol A1BG contributors: mct - updated : 27-10-2011
HGNC name alpha-1-B glycoprotein
HGNC id 5
Location 19q13.43      Physical location : 58.858.173 - 58.864.865
Synonym symbol(s) A1B, ABG, GAB, HYST2477, DKFZp686F0970
DNA
TYPE functioning gene
STRUCTURE 6.69 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1766 - 495 - 2004 15461460
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Reproductivefemale systembreastmammary gland highly
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five Ig-like V-type (immunoglobulin-like) domains
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • immunoglobulin C-2 type family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potentially A1BG-CRISP3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP3
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexed with CRISP3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP3 is a specific and high-affinity ligand of A1BG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in endometrium from ectopic when compared with intrauterine pregnancies
    tumoral     --over  
    in cancerous pancreatic juice from pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker in pancreatic cancer
  • a 13.8&
    • 8201;kDa A1BG fragment having a high discriminatory power for steroid resistance in pediatric nephrotic syndrome, but is only present in a subset of patients
    Therapy target
    ANIMAL & CELL MODELS