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FLASH GENE
Symbol A1BG contributors: mct - updated : 27-10-2011
HGNC name alpha-1-B glycoprotein
HGNC id 5
Location 19q13.43      Physical location : 58.858.173 - 58.864.865
Synonym symbol(s) A1B, ABG, GAB, HYST2477, DKFZp686F0970
DNA
TYPE functioning gene
STRUCTURE 6.69 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
MGC34079 19q13.43 hypothetical protein MGC34079 KIAA1956 19q13.43 KIAA1956 protein ZNF256 19q13.43 zinc finger protein 256 LOC390983 19 similar to 60S ribosomal protein L19 MGC41906 19q13.43 hypothetical protein MGC41906 FLJ14260 19q13.4 hypothetical protein FLJ14260 LOC390984 19 similar to putative pheromone receptor FLJ33779 19q13.43 hypothetical protein FLJ33779 ZNF135 19q13.4 zinc finger protein 135 (clone pHZ-17) FLJ12895 19q13.43 hypothetical protein FLJ12895 LOC390985 19 similar to hypothetical protein FLJ12586 FLJ12586 19q13.43 hypothetical protein FLJ12586 ZNF274 19q13.43 zinc finger protein 274 LOC125910 19q13.43 similar to 40S ribosomal protein S15a LOC388568 19 LOC388568 AF020591 ZNF8 19q13.43 zinc finger protein 8 (clone HF.18) LOC113386 19q13.43 similar to envelope protein LOC390986 19 similar to zinc finger protein 135 (clone pHZ-17); zinc finger protein 61 HKR2 19pter-p13.3 GLI-Kruppel family member HKR2 A1BG 19q11-q13.2 alpha-1-B glycoprotein ZNF497 19q13.43 zinc finger protein 497 RPS5 19q13.4 ribosomal protein S5 FLJ39005 19q13.43 hypothetical protein FLJ39005 LOC201514 19q13.43 hypothetical protein LOC201514 ZNF132 19q13.4 zinc finger protein 132 (clone pHZ-12) LOC388569 19 similar to Zinc finger protein 324 (Zinc finger protein ZF5128) ZNF324 19q13.43 zinc finger protein 324 FLJ20626 19q13.43 hypothetical protein FLJ20626 SLC27A5 19q13.4 solute carrier family 27 (fatty acid transporter), member 5 ZNF499 19q13.43 zinc finger protein 499 TRIM28 5p13.3-p13.2 tripartite motif-containing 28 BC-2 19q putative breast adenocarcinoma marker (32kD) UBE2M 19q13.43 ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) ZNF42 19q13.4 zinc finger protein 42 (myeloid-specific retinoic acid- responsive) MGC2752 19p13.2 hypothetical protein MGC2752
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1766 - 495 - 2004 15461460
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   predominantly
Reproductivefemale systembreastmammary gland highly
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five Ig-like V-type (immunoglobulin-like) domains
    • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • immunoglobulin C-2 type family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potentially A1BG-CRISP3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP3
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexed with CRISP3
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP3 is a specific and high-affinity ligand of A1BG
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in endometrium from ectopic when compared with intrauterine pregnancies
    tumoral     --over  
    in cancerous pancreatic juice from pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker in pancreatic cancer
  • a 13.8&
    • 8201;kDa A1BG fragment having a high discriminatory power for steroid resistance in pediatric nephrotic syndrome, but is only present in a subset of patients
    Therapy target
    ANIMAL & CELL MODELS