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FLASH GENE
Symbol FZD4 contributors: mct/shn - updated : 16-05-2014
HGNC name frizzled homolog 4 (Drosophila)
HGNC id 4042
ANIMAL & CELL MODELS
  • FZD4-/- mice exhibit a progressive cerebellar degeneration, auditory and esophageal dysfunction (Wang et al, 2001)
  • loss of Fz4 signaling in endothelial murin cells causes defective vascular growth leading to chronic but reversible silencing of retinal neurons leading to visual dfects and disrupts the blood brain barrier in the cerebellum (Ye et al, 2009)