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FLASH GENE
Symbol GRM5 contributors: mct/pgu - updated : 11-01-2015
HGNC name glutamate receptor, metabotropic 5
HGNC id 4597
ANIMAL & CELL MODELS
  • Mice lacking metabotropic glutamate receptors 5 (mGluR5) exhibit reduced glutamatergic function and behavioral abnormalities, including deficits in prepulse inhibition (PPI) of the startle response that may be relevant to schizophrenia
  • dysregulation of Fmrp-Grm5 signaling pathway, accompanied with a downregulation of Gabrb3 expression, may contribute to the 'autistic-like' features observed in En2 mice