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Symbol ATG5 contributors: mct/ - updated : 24-10-2018
HGNC name ATG5 autophagy related 5 homolog (S. cerevisiae)
HGNC id 589
  • All Atg5-null mice died within 1 day of delivery, the survival time of starved Atg5-deficient neonates (approximately 12 hours) was much shorter than that of wildtype mice (approximately 21 hours). Atg5-deficient neonates exhibited reduced amino acid concentrations in plasma and tissues and displayed signs of energy depletion. Neonates adapt to immediate post-birth starvation by inducing autophagy
  • mice deficient for Atg5 or Atg7 specifically in the dopaminergic neurons were less sensitive to developing a morphine reward response, behavioral sensitization, analgesic tolerance and physical dependence compared to wild-type mice
  • Atg5-deficient mice displayed abnormal Tbx2 expression and defects in valve development and chamber septation