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Symbol IRS2 contributors: mct/npt/pgu - updated : 12-06-2015
HGNC name insulin receptor substrate 2
HGNC id 6126
  • irs2-/- mice
  • chico-/-drosophila
  • chronic hyperinsulinemia downregulates the mRNA for IRS2 in ob/ob mice
  • female infertility caused by deletion of IRS2
  • less Irs2 signaling in aging brains can promote healthy metabolism, attenuate meal-induced oxidative stress, and extend the life span of overweight and insulin-resistant mice
  • Irs2-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function
  • liver content of GCK was reduced in Irs2(-/-) mice as compared with controls, although GCKR levels were similar
  • Irs2 (-/-) mice also exhibited reduced testicular size, suggesting that impairments in this model occur during development
  • complete disruption of Irs2 in mice impairs long-term potentiation (LTP) of synaptic transmission in the hippocampus