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FLASH GENE
Symbol TNFRSF11B contributors: mct/npt/shn - updated : 19-09-2015
HGNC name tumor necrosis factor receptor superfamily, member 11b
HGNC id 11909
ANIMAL & CELL MODELS
  • OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the skull, and a high incidence of fractures
  • OCIF/OPG knockout mice are viable and fertile but exhibit severe osteoporosis due to enhanced osteoclastogenesis, and marked bone loss accompanied by destruction of growth plate and lack of trabecular bone in their femurs