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FLASH GENE

Symbol

TNFRSF11B

contributors: mct/npt/shn - updated : 19-09-2015

HGNC name	tumor necrosis factor receptor superfamily, member 11b
HGNC id	11909

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	OPG-/- mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the skull, and a high incidence of fractures
	OCIF/OPG knockout mice are viable and fertile but exhibit severe osteoporosis due to enhanced osteoclastogenesis, and marked bone loss accompanied by destruction of growth plate and lack of trabecular bone in their femurs