Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CUL4B contributors: mct - updated : 09-10-2017
HGNC name cullin 4B
HGNC id 2555
ANIMAL & CELL MODELS
  • RNA interference silencing of CUL4B led to an inhibition of cell proliferation and a prolonged S phase, due to the overaccumulation of cyclin E (
  • Knocking down CUL4B increases WDR5 and trimethylated H3K4 on the neuronal gene promoters and induces their expression (
  • CUL4B depletion suppresses neurite outgrowth of PC12 neuroendocrine cells (
  • Cul4b null mouse embryos show severe developmental arrest and usually die before embryonic day 9.5 (E9.5)