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FLASH GENE
Symbol ICOSLG contributors: mct - updated : 02-01-2017
HGNC name inducible T-cell co-stimulator ligand
HGNC id 17087
ANIMAL & CELL MODELS
Icosl -/- mice are healthy and fertile but have a reduced IgG1 production and affinity maturation, indicating a defect in T cell responses. Also have impaired T and B-cell interaction and germinal center formation