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FLASH GENE
Symbol CELSR3 contributors: mct/shn/pgu - updated : 19-09-2010
HGNC name cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
HGNC id 3230
ANIMAL & CELL MODELS
  • mice with inactivated Celsr3 gene display selective anomalies of several major axonal fascicles implicating protocadherins in axonal development
  • null mutation of Celsr3 in mice leads to defective anterior commissure and internal capsule of the axonal tracts
  • Celsr2/Celsr3 double mutant mice display markedly impairment of ependyma and ciliogenesis leading to lethal hydrocephalus