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FLASH GENE
Symbol SPG7 contributors: mct/npt - updated : 09-04-2020
HGNC name SPG7 matrix AAA peptidase subunit, paraplegin
HGNC id 11237
ANIMAL & CELL MODELS
  • Drosophila Spg7 mutants exhibited shortened lifespan, progressive locomotor defects, sensitivity to chemical and environmental stress, and muscular and neuronal degeneration
  • mouse model of Spg7-linked hereditary spastic paraplegia is an isoform-specific knock-out, in which mitochondrial paraplegin is specifically ablated, while expression of paraplegin-2 is retained