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FLASH GENE
Symbol MARK3 contributors: mct/pgu - updated : 21-08-2010
HGNC name MAP/microtubule affinity-regulating kinase 3
HGNC id 6897
ANIMAL & CELL MODELS
  • Par-1a/ mice are viable and develop normally, and adult mice are hypermetabolic, have decreased white and brown adipose tissue mass, and unaltered glucose/insulin handling, but show resistance to glucose intolerance on high-fat diet, and diet-dependent reduced adiposity
  • Par-1b/Par-1a double mutants are not viable, and at least one allele is necessary for embryonic survival