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FLASH GENE
Symbol KIF3A contributors: shn/npt/pgu - updated : 07-09-2016
HGNC name kinesin family member 3A
HGNC id 6319
ANIMAL & CELL MODELS
  • mouse mutants lacking the KIF3A showed situs inversus and embryonic ciliary morphogenesis defects
  • mouse embryos lacking KIF3A die at 10 days postcoitum, exhibit randomized establishment of L-R asymmetry and display numerous structural abnormalities
  • complete loss of Kif3a led to large accumulations of opsin, arrestin and membranes within the photoreceptor inner segment and caused apoptotic photoreceptor cell death
  • Kif3a mutant zebrafish exhibited curved body axes and kidney cysts