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FLASH GENE
Symbol CASP4 contributors: shn/npt/pgu - updated : 02-06-2013
HGNC name caspase 4, apoptosis-related cysteine peptidase
HGNC id 1505
ANIMAL & CELL MODELS
  • knock-down of CASP4 by siRNA reduces NF-kappaB activation and nuclear translocation
  • Casp11(-/-) mice, exhibited defects in IL-1&
  • 946; production and harboured a mutation in the Casp11 locus that attenuated caspase-11 expression
  • loss of caspase-11 rather than caspase-1 protected mice from a lethal dose of lipopolysaccharide