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FLASH GENE
Symbol MYOC contributors: shn - updated : 18-04-2012
HGNC name myocilin, trabecular meshwork inducible glucocorticoid response
HGNC id 7610
ANIMAL & CELL MODELS
  • mouse heterozygous and homozygous for a targeted null mutation in Myoc gene are both viable and fertile, and Myoc is not required for normal intraocular pressure or normal ocular morphology (
  • lenses of transgenic mice expressing the Human mutated Tyr437His myocilin developed nuclear cataracts, completely lost transparency, and eventually ruptured (
  • Expression of human myocilin glaucomatous mutations in mouse eyes causes elevated intraocular pressure, which is a major phenotype of MYOC glaucoma (
  • increased skeletal muscle mass in myocilin-expressing transgenic mice compared with wild-type mice