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FLASH GENE
Symbol TAZ contributors: mct/npt/pgu - updated : 27-11-2015
HGNC name tafazzin
HGNC id 11577
ANIMAL & CELL MODELS
  • defects of cardiac mitochondria and mitochondrion-associated membranes in taz-deficient mice, and cardiac muscle and skeletal muscle of tafazzin-deficient mice demonstrate ultrastructural defects, including mitochondrial proliferation, myofibrillar disarray, mitophagy
  • Tafazzin-knockdown in mice markedly impaired oxygen consumption rates during an exercise, without any significant effect on resting metabolic rates
  • Taz deficiency in mouse embryonic fibroblasts (MEFs) also led to impaired oxidative phosphorylation and severe oxidative stress