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FLASH GENE
Symbol EGR1 contributors: mct/shn - updated : 09-11-2015
HGNC name early growth response 1
HGNC id 3238
ANIMAL & CELL MODELS
  • NGFI-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-beta deficiency (
  • repression of Egr-1 expression drastically inhibits UVB-mediated cell death (
  • Egr-1 knockout mice had longer eyes and a relative myopic shift in refraction, with additional minor effects on anterior chamber depth and corneal radius of curvature (
  • Egr1(+/-) and Egr1(-/-) mice treated with ENU developed immature T-cell lymphomas (CD4(+), CD8(+)) or a myeloproliferative disorder characterized by an elevated white blood cell count, anemia, and thrombocytopenia with ineffective erythropoiesis at increased rates and with shorter latencies than that of wild-type littermates (