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FLASH GENE
Symbol MEF2C contributors: mct/ - updated : 18-08-2015
HGNC name myocyte enhancer factor 2C
HGNC id 6996
ANIMAL & CELL MODELS
  • mice displayed autistic phenotypes resembling Rett syndrome in that they manifested altered anxiety and increased stereotypy (purposeless movements) on neurobehavioral testing, representing key characteristics of autism-spectrum disorders
  • inactivation of Mef2c in the neural crest of mice results in reduced expression of melanocyte genes during development and a significant loss of pigmentation at birth due to defective differentiation and reduced abundance of melanocytes