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FLASH GENE
Symbol CREB1 contributors: mct/shn - updated : 08-06-2016
HGNC name cAMP responsive element binding protein 1
HGNC id 2345
ANIMAL & CELL MODELS
  • transgenic mice expressing a dominant-negative form of the CREB1 develop dilated cardiomyopathy associated with hepatic congestion and peripheral edema, intracardiac thrombi, and premature mortality
  • CREB null mice are smaller, display a strong reduction in the corpus callosum and the anterior commissures in brain and die immediately after birth from respiratory distress
  • mice with a disruption of CREB1exhibit fasting hypoglycaemia and reduced expression of gluconeogenic enzymes
  • disrupted Creb1 and Crem in brain of developing and adult mice using the Cre/loxP system leads to progressive neurodegeneration in the hippocampus and in the dorsolateral striatum
  • mice harboring a null mutation in the Creb gene, sensory neurons exhibit excess apoptosis and degeneration, and display impaired axonal growth and projections
  • mice deficient in CREB activity have a fatty liver phenotype and display elevated expression of the nuclear hormone receptor PPAR-gamma (ID: 14614508)
  • mice expressing a dominant-negative CREB transgene exhibit a dystrophic phenotype along with reduced MEF2 activity