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FLASH GENE
Symbol XBP1 contributors: mct - updated : 06-09-2016
HGNC name X-box binding protein 1
HGNC id 12801
ANIMAL & CELL MODELS
  • mutant SOD1 transgenic mice with specific deletion of XBP-1 in the nervous system were more resistant to developing disease, correlating with increased levels of autophagy in motoneurons and reduced accumulation of mutant SOD1 aggregates in the spinal cord
  • Xbp1-deficient mice were more resistant to developing disease features, associated with improved neuronal survival and motor performance, and a drastic decrease in mHtt levels