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FLASH GENE
Symbol PDSS2 contributors: mct/npt - updated : 11-05-2021
HGNC name prenyl (decaprenyl) diphosphate synthase, subunit 2
HGNC id 23041
ANIMAL & CELL MODELS
  • during cerebellum development, Pdss2 knockout results in severe cerebellum hypoplasia by impairing cell migration and eliciting ectopic apoptosis, whereas Pdss2 knockout in Purkinje cells at postnatal stages leads to the development of cerebellar ataxia
  • both conditional knockout and missense mutant mice demonstrate deficiencies in tyrosine hydroxylase-positive neurons in the substantia nigra, implicating a pathology similar to sporadic Parkinson's disease (PD)